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KMID : 0378019940370100055
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New Medical Journal
1994 Volume.37 No. 10 p.55 ~ p.66
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A Study on the Metallothionein Concentration and Lactate Dehydrogenase Activity in the Organs of Acutely Intoxicated Rats by Cadmium
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Abstract
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Tolerance to toxic effects of cadmium(Cd), including lethality has been shown following pretreatment with cadmium and zinc. This study was designed to determine if tolerance also develops to Cd-induced hepatotoxicity and renal toxicity.
Three groups of rats (A, B, Q), each consisting of 36 rats, were studied and each group was divided into three subgroups (1, 2, 3), 12 rats for each subgroup.
Rats were subcutaneously pretreated with saline(A), CdC12(0.5mg/kg , B), and ZnCl2 (13.0 mg/kg, C) during time periods of 5 day. At the end of the period, rats were challenged with CdC12 (3.0 and 6.0 mg/kg) by intraperitoneal injection.
After 24, 48 hours of intraperitoneal injection by challenge doses the concentration of cadmium and lactate dehydrogenase (LDH) activity in liver and kidney increased proportionally to the increase of challenge dosage.
However metallothioneins in liver and kidney were increased by the pretreatment of cadmium and zinc.
These data indicate the liver is a major target organ of acute Cd poisoning, and suggest that cadmium induced hepatic injury, via release of Cd-MT, may play an important role in the nephrotoxicity observed in response to short-term exposure to cadmium.
This result suggest that increasing cadmium concentrations, gradually accumulating in liver and kidney as the result of the pretreatment, served to induced the synthesis of metallothionein, thus making them resistant to the challenge from cadmium.
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